Methotrexat Ebewe Dosage/Direction for Use

Posology: The tablets should be taken 1 hour before or 1.5-2 hours after a meal.
Rheumatoid arthritis and psoriasis: The product should be used by specialists in dermatology, rheumatology and internal medicine.
Psoriasis: The recommended initial dose is 2.5mg 3 times per week with 12 hours interval alternatively one single dose of 7.5mg once a week.
Rheumatoid arthritis: Initial dose of 7.5mg per week given as a single dose.
For both dose regimens, the therapeutic effect is obtained usually within 6 weeks with the condition of the patient improving after another 12 weeks or more. If no response has been achieved after 6-8 weeks and no toxic symptoms are observed the dose can be increased stepwise by 2.5mg/week.
Usually the optimum dose per week is between 7.5-16mg and the dose should not exceed 20mg/week. If no response is obtained after 8 weeks with the maximum dose, methotrexate should be withdrawn. When response to the treatment effect has been achieved the maintenance dose should be reduced to the lowest possible. The optimal therapy duration is so far unknown but preliminary data indicates that the initially achieved effect may remain for at least 2 years with continued maintenance dose. When the treatment is withdrawn the symptoms may return within 3-6 weeks.
Cytostatic: Oral administration of methotrexate in doses up to 30mg/m² is possible while higher doses should be given parenterally. Oral treatment with doses up to 20mg/m² per week should be used together with intravenous administration and intrathecal CNS-prophylaxis as maintenance treatment in acute lymphatic leukaemia (ALL) in children.